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Clinical Implications of Basic Research
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Volume 350:2516-2517 June 10, 2004 Number 24
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Erythropoietin for Neurologic Protection and Diabetic Neuropathy
Stuart A. Lipton, M.D., Ph.D.

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The majority of drugs developed for neurologic indications fail because they are not clinically tolerated. A sensible strategy, therefore, is to explore the efficacy of drugs in the nervous system that have already been approved for other indications. When I was in medical school, erythropoietin was known to be a cytokine produced in the kidney and was thought to be important only for the development of red cells, which bear receptors for erythropoietin. But recent results have shown that nerve cells also have erythropoietin receptors and that this cytokine is made in the nervous system and can function as a . . . [Full Text of this Article]


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From the Burnham Institute, the Salk Institute for Biological Studies, the Scripps Research Institute, and the University of California at San Diego — all in La Jolla.


Related Letters:

Erythropoietin, Glutamate, and Neuroprotection
Roesler R., Quevedo J., Schroder N., Lipton S. A.
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N Engl J Med 2004; 351:1465-1466, Sep 30, 2004. Correspondence

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