FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 350:2682-2688 June 24, 2004 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Perspective by McNally, E. M. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

Muscle wasting and weakness are among the most common inherited and acquired disorders and include the muscular dystrophies, cachexia, and age-related wasting. Since there is no generally accepted treatment to improve muscle bulk and strength, these conditions pose a substantial burden to patients as well as to public health. Consequently, there has been considerable interest in a recently described inhibitor of muscle growth, myostatin, or growth/differentiation factor 8 (GDF-8), which belongs to the transforming growth factor superfamily of secreted proteins that control the growth and differentiation of tissues throughout the body. The myostatin gene is expressed almost exclusively in cells . . . [Full Text of this Article]

Case Report

Methods

Results

Imaging

Molecular Biology

Discussion

Source Information

From the Departments of Neuropediatrics (M.S., C.H.), Pediatric Radiology (T.R.), and Neonatology (W.K.), Charité, University Medical Center Berlin, Berlin; the Departments of Neurology (K.R.W.) and Molecular Biology and Genetics (S.-J.L.), Johns Hopkins University School of Medicine, Baltimore; the Department of Cardiovascular and Metabolic Diseases, Wyeth Research, Cambridge, Mass. (L.E.S., J.F.T.); and the Institute of Physiological Chemistry, Martin Luther University, Halle-Wittenberg, Germany (T.B.).

Address reprint requests to Dr. Schuelke at the Department of Neuropediatrics, Charité, University Medical Center Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, or at markus.schuelke@charite.de.

Related Letters:

Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child
atipovi B., Williams M. S., Uhlenberg B., Lucke B., Schuelke M.
Extract | Full Text | PDF  
N Engl J Med 2004; 351:1030-1031, Sep 2, 2004. Correspondence

This article has been cited by other articles:

• Sartori, R., Milan, G., Patron, M., Mammucari, C., Blaauw, B., Abraham, R., Sandri, M. (2009). Smad2 and 3 transcription factors control muscle mass in adulthood. Am. J. Physiol. Cell Physiol. 296: C1248-C1257 [Abstract] [Full Text]  
• Welle, S. L. (2009). Myostatin and muscle fiber size. Focus on "Smad2 and 3 transcription factors control muscle mass in adulthood" and "Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size". Am. J. Physiol. Cell Physiol. 296: C1245-C1247 [Full Text]  
• LeBrasseur, N. K., Schelhorn, T. M., Bernardo, B. L., Cosgrove, P. G., Loria, P. M., Brown, T. A. (2009). Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice. J Gerontol A Biol Sci Med Sci 0: glp068v1-glp068 [Abstract] [Full Text]  
• Wen, T., Peng, B., Pintar, J. E. (2009). The MOR-1 Opioid Receptor Regulates Glucose Homeostasis by Modulating Insulin Secretion. Mol. Endocrinol. 23: 671-678 [Abstract] [Full Text]  
• Hulmi, J. J., Tannerstedt, J., Selanne, H., Kainulainen, H., Kovanen, V., Mero, A. A. (2009). Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men. J. Appl. Physiol. 106: 1720-1729 [Abstract] [Full Text]  
• Rose, F. F. Jr, Mattis, V. B., Rindt, H., Lorson, C. L. (2009). Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy. Hum Mol Genet 18: 997-1005 [Abstract] [Full Text]  
• Welle, S., Burgess, K., Mehta, S. (2009). Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice. Am. J. Physiol. Endocrinol. Metab. 296: E567-E572 [Abstract] [Full Text]  
• Ciarmela, P., Wiater, E., Smith, S. M., Vale, W. (2009). Presence, Actions, and Regulation of Myostatin in Rat Uterus and Myometrial Cells. Endocrinology 150: 906-914 [Abstract] [Full Text]  
• Souza, T. A., Chen, X., Guo, Y., Sava, P., Zhang, J., Hill, J. J., Yaworsky, P. J., Qiu, Y. (2008). Proteomic Identification and Functional Validation of Activins and Bone Morphogenetic Protein 11 as Candidate Novel Muscle Mass Regulators. Mol. Endocrinol. 22: 2689-2702 [Abstract] [Full Text]  
• Rodgers, B. D., Garikipati, D. K. (2008). Clinical, Agricultural, and Evolutionary Biology of Myostatin: A Comparative Review. Endocr. Rev. 29: 513-534 [Abstract] [Full Text]  
• Li, Z. B., Kollias, H. D., Wagner, K. R. (2008). Myostatin Directly Regulates Skeletal Muscle Fibrosis. J. Biol. Chem. 283: 19371-19378 [Abstract] [Full Text]  
• Sandri, M. (2008). Signaling in Muscle Atrophy and Hypertrophy. Physiology 23: 160-170 [Abstract] [Full Text]  
• Diel, P, Baadners, D, Schlupmann, K, Velders, M, Schwarz, J P (2008). C2C12 myoblastoma cell differentiation and proliferation is stimulated by androgens and associated with a modulation of myostatin and Pax7 expression. J Mol Endocrinol 40: 231-241 [Abstract] [Full Text]  
• Allen, D. L., Cleary, A. S., Speaker, K. J., Lindsay, S. F., Uyenishi, J., Reed, J. M., Madden, M. C., Mehan, R. S. (2008). Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice. Am. J. Physiol. Endocrinol. Metab. 294: E918-E927 [Abstract] [Full Text]  
• Guo, W., Flanagan, J., Jasuja, R., Kirkland, J., Jiang, L., Bhasin, S. (2008). The Effects of Myostatin on Adipogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells Are Mediated through Cross-communication between Smad3 and Wnt/{beta}-Catenin Signaling Pathways. J. Biol. Chem. 283: 9136-9145 [Abstract] [Full Text]  
• Kollias, H. D., McDermott, J. C. (2008). Transforming growth factor-{beta} and myostatin signaling in skeletal muscle. J. Appl. Physiol. 104: 579-587 [Abstract] [Full Text]  
• Manceau, M., Gros, J., Savage, K., Thome, V., McPherron, A., Paterson, B., Marcelle, C. (2008). Myostatin promotes the terminal differentiation of embryonic muscle progenitors. Genes Dev. 22: 668-681 [Abstract] [Full Text]  
• Nakatani, M., Takehara, Y., Sugino, H., Matsumoto, M., Hashimoto, O., Hasegawa, Y., Murakami, T., Uezumi, A., Takeda, S., Noji, S., Sunada, Y., Tsuchida, K. (2008). Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice. FASEB J. 22: 477-487 [Abstract] [Full Text]  
• Nakano, N., Hori, H., Abe, M., Shibata, H., Arimura, T., Sasaoka, T., Sawabe, M., Chida, K., Arai, T., Nakahara, K.-i., Kubo, T., Sugimoto, K., Katsuya, T., Ogihara, T., Doi, Y., Izumi, T., Kimura, A. (2007). Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 293: H3396-H3403 [Abstract] [Full Text]  
• Vecchione, L., Byron, C., Cooper, G.M., Barbano, T., Hamrick, M.W., Sciote, J.J., Mooney, M.P. (2007). Craniofacial Morphology in Myostatin-deficient Mice. JDR 86: 1068-1072 [Abstract] [Full Text]  
• Kim, J.-s., Petrella, J. K., Cross, J. M., Bamman, M. M. (2007). Load-mediated downregulation of myostatin mRNA is not sufficient to promote myofiber hypertrophy in humans: a cluster analysis. J. Appl. Physiol. 103: 1488-1495 [Abstract] [Full Text]  
• Antony, N., Bass, J. J., McMahon, C. D., Mitchell, M. D. (2007). Myostatin regulates glucose uptake in BeWo cells. Am. J. Physiol. Endocrinol. Metab. 293: E1296-E1302 [Abstract] [Full Text]  
• Harridge, S. D. R. (2007). Plasticity of human skeletal muscle: gene expression to in vivo function. Exp Physiol 92: 783-797 [Abstract] [Full Text]  
• Takaoka, Y., Ohta, M., Ito, A., Takamatsu, K., Sugano, A., Funakoshi, K., Takaoka, N., Sato, N., Yokozaki, H., Arizono, N., Goto, S., Maeda, E. (2007). Electroacupuncture suppresses myostatin gene expression: cell proliferative reaction in mouse skeletal muscle. Physiol. Genomics 30: 102-110 [Abstract] [Full Text]  
• Artaza, J. N, Reisz-Porszasz, S., Dow, J. S, Kloner, R. A, Tsao, J., Bhasin, S., Gonzalez-Cadavid, N. F (2007). Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse. J Endocrinol 194: 63-76 [Abstract] [Full Text]  
• Walsh, S., Metter, E. J., Ferrucci, L., Roth, S. M. (2007). Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J. Appl. Physiol. 102: 2142-2148 [Abstract] [Full Text]  
• Kim, Y. S., Bobbili, N. K., Lee, Y. K., Jin, H. J., Dunn, M. A. (2007). Production of a Polyclonal Anti-Myostatin Antibody and the Effects of In Ovo Administration of the Antibody on Posthatch Broiler Growth and Muscle Mass. Poult. Sci. 86: 1196-1205 [Abstract] [Full Text]  
• Garikipati, D. K., Gahr, S. A., Roalson, E. H., Rodgers, B. D. (2007). Characterization of Rainbow Trout Myostatin-2 Genes (rtMSTN-2a and -2b): Genomic Organization, Differential Expression, and Pseudogenization. Endocrinology 148: 2106-2115 [Abstract] [Full Text]  
• McKoy, G., Bicknell, K. A., Patel, K., Brooks, G. (2007). Developmental expression of myostatin in cardiomyocytes and its effect on foetal and neonatal rat cardiomyocyte proliferation. Cardiovasc Res 74: 304-312 [Abstract] [Full Text]  
• Pescatori, M., Broccolini, A., Minetti, C., Bertini, E., Bruno, C., D'amico, A., Bernardini, C., Mirabella, M., Silvestri, G., Giglio, V., Modoni, A., Pedemonte, M., Tasca, G., Galluzzi, G., Mercuri, E., Tonali, P. A., Ricci, E. (2007). Gene expression profiling in the early phases of DMD: a constant molecular signature characterizes DMD muscle from early postnatal life throughout disease progression. FASEB J. 21: 1210-1226 [Abstract] [Full Text]  
• Spuler, S., Kalbhenn, T., Zabojszcza, J., van Landeghem, F.K.H., Ludtke, A., Wenzel, K., Koehnlein, M., Schuelke, M., Ludemann, L., Schmidt, H. H. (2007). Muscle and nerve pathology in Dunnigan familial partial lipodystrophy. Neurology 68: 677-683 [Abstract] [Full Text]  
• Yang, W., Zhang, Y., Li, Y., Wu, Z., Zhu, D. (2007). Myostatin Induces Cyclin D1 Degradation to Cause Cell Cycle Arrest through a Phosphatidylinositol 3-Kinase/AKT/GSK-3beta Pathway and Is Antagonized by Insulin-like Growth Factor 1. J. Biol. Chem. 282: 3799-3808 [Abstract] [Full Text]  
• Amthor, H., Macharia, R., Navarrete, R., Schuelke, M., Brown, S. C., Otto, A., Voit, T., Muntoni, F., Vrbova, G., Partridge, T., Zammit, P., Bunger, L., Patel, K. (2007). Lack of myostatin results in excessive muscle growth but impaired force generation. Proc. Natl. Acad. Sci. USA 104: 1835-1840 [Abstract] [Full Text]  
• Mukherjee, A., Sidis, Y., Mahan, A., Raher, M. J., Xia, Y., Rosen, E. D., Bloch, K. D., Thomas, M. K., Schneyer, A. L. (2007). FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc. Natl. Acad. Sci. USA 104: 1348-1353 [Abstract] [Full Text]  
• Castro-Gago, M., Gomez-Lado, C., Eiris-Punal, J., Carneiro, I., Arce, V. M., Devesa, J. (2007). Muscle Myostatin Expression in Children With Muscle Diseases. J Child Neurol 22: 38-40 [Abstract]  
• Allen, D. L., Unterman, T. G. (2007). Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors. Am. J. Physiol. Cell Physiol. 292: C188-C199 [Abstract] [Full Text]  
• Solomon, A M, Bouloux, P M G (2006). Modifying muscle mass - the endocrine perspective.. J Endocrinol 191: 349-360 [Abstract] [Full Text]  
• Pearen, M. A., Ryall, J. G., Maxwell, M. A., Ohkura, N., Lynch, G. S., Muscat, G. E. O. (2006). The Orphan Nuclear Receptor, NOR-1, Is a Target of {beta}-Adrenergic Signaling in Skeletal Muscle. Endocrinology 147: 5217-5227 [Abstract] [Full Text]  
• Wilson, E. M., Rotwein, P. (2006). Control of MyoD Function during Initiation of Muscle Differentiation by an Autocrine Signaling Pathway Activated by Insulin-like Growth Factor-II. J. Biol. Chem. 281: 29962-29971 [Abstract] [Full Text]  
• Oudit, G.Y., Herzenberg, A.M., Kassiri, Z., Wong, D., Reich, H., Khokha, R., Crackower, M.A., Backx, P.H., Penninger, J.M., Scholey, J.W., Percy, M.J., Zhao Q., F. A., Harrison, C., Lappin, T.R., Maxwell, P.H., McMullin, M.F., Lee, F.S. (2006). Angiotensin-Converting Enzyme-2 (ACE2)--A New Player in the Genesis of Glomerular Injury?: Loss of Angiotensin-Converting Enzyme-2 Leads to the Late Development of Angiotensin II-Dependent Glomerulosclerosis. Am J Pathol 168: 1808-1820, 2006. J. Am. Soc. Nephrol. 17: 2637-2643 [Full Text]  
• Garikipati, D. K, Gahr, S. A, Rodgers, B. D (2006). Identification, characterization, and quantitative expression analysis of rainbow trout myostatin-1a and myostatin-1b genes.. J Endocrinol 190: 879-888 [Abstract] [Full Text]  
• Mendias, C. L., Marcin, J. E., Calerdon, D. R., Faulkner, J. A. (2006). Contractile properties of EDL and soleus muscles of myostatin-deficient mice. J. Appl. Physiol. 101: 898-905 [Abstract] [Full Text]  
• Sato, F., Kurokawa, M., Yamauchi, N., Hattori, M.-a. (2006). Gene silencing of myostatin in differentiation of chicken embryonic myoblasts by small interfering RNA. Am. J. Physiol. Cell Physiol. 291: C538-C545 [Abstract] [Full Text]  
• Morissette, M. R., Cook, S. A., Foo, S., McKoy, G., Ashida, N., Novikov, M., Scherrer-Crosbie, M., Li, L., Matsui, T., Brooks, G., Rosenzweig, A. (2006). Myostatin Regulates Cardiomyocyte Growth Through Modulation of Akt Signaling. Circ. Res. 99: 15-24 [Abstract] [Full Text]  
• Welle, S., Bhatt, K., Pinkert, C. A. (2006). Myofibrillar protein synthesis in myostatin-deficient mice. Am. J. Physiol. Endocrinol. Metab. 290: E409-E415 [Abstract] [Full Text]  
• Yang, W., Chen, Y., Zhang, Y., Wang, X., Yang, N., Zhu, D. (2006). Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase Pathway Is Involved in Myostatin-Regulated Differentiation Repression. Cancer Res. 66: 1320-1326 [Abstract] [Full Text]  
• Askanas, V., Engel, W. K. (2006). Inclusion-body myositis: A myodegenerative conformational disorder associated with A{beta}, protein misfolding, and proteasome inhibition. Neurology 66: S39-S48 [Abstract] [Full Text]  
• GEORGES, M., CLOP, A., MARCQ, F., TAKEDA, H., PIROTTIN, D., HIARD, S., TORDOIR, X., CAIMENT, F., MEISH, F., BIBE, B., BOUIX, J., ELSEN, J.M., EYCHENNE, F., LAVILLE, E., LARZUL, C., MILENKOVIC, D., TOBIN, J., CHARLIER, A. C. (2006). Polymorphic Polymorphic MicroRNA-Target Interactions: A Novel Source of Phenotypic Variation. Cold Spring Harb Symp Quant Biol 71: 343-350 [Abstract]  
• Lee, S.-J., Reed, L. A., Davies, M. V., Girgenrath, S., Goad, M. E. P., Tomkinson, K. N., Wright, J. F., Barker, C., Ehrmantraut, G., Holmstrom, J., Trowell, B., Gertz, B., Jiang, M.-S., Sebald, S. M., Matzuk, M., Li, E., Liang, L.-f., Quattlebaum, E., Stotish, R. L., Wolfman, N. M. (2005). Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc. Natl. Acad. Sci. USA 102: 18117-18122 [Abstract] [Full Text]  
• Womack, J. E. (2005). Advances in livestock genomics: Opening the barn door. Genome Res 15: 1699-1705 [Abstract] [Full Text]  
• Muenster, U., Harrison, C. A., Donaldson, C., Vale, W., Fischer, W. H. (2005). An Activin-A/C Chimera Exhibits Activin and Myostatin Antagonistic Properties. J. Biol. Chem. 280: 36626-36632 [Abstract] [Full Text]  
• Wenzel, K., Zabojszcza, J., Carl, M., Taubert, S., Lass, A., Harris, C. L., Ho, M., Schulz, H., Hummel, O., Hubner, N., Osterziel, K. J., Spuler, S. (2005). Increased Susceptibility to Complement Attack due to Down-Regulation of Decay-Accelerating Factor/CD55 in Dysferlin-Deficient Muscular Dystrophy. J. Immunol. 175: 6219-6225 [Abstract] [Full Text]  
• Huygens, W., Thomis, M. A. I., Peeters, M. W., Aerssens, J., Vlietinck, R., Beunen, G. P. (2005). Quantitative trait loci for human muscle strength: linkage analysis of myostatin pathway genes. Physiol. Genomics 22: 390-397 [Abstract] [Full Text]  
• Artaza, J. N., Bhasin, S., Magee, T. R., Reisz-Porszasz, S., Shen, R., Groome, N. P., Fareez, M. M., Gonzalez-Cadavid, N. F. (2005). Myostatin Inhibits Myogenesis and Promotes Adipogenesis in C3H 10T(1/2) Mesenchymal Multipotent Cells. Endocrinology 146: 3547-3557 [Abstract] [Full Text]  
• Chen, Y., Zajac, J. D, MacLean, H. E (2005). Androgen regulation of satellite cell function. J Endocrinol 186: 21-31 [Abstract] [Full Text]  
• Kim, J.-s., Cross, J. M., Bamman, M. M. (2005). Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women. Am. J. Physiol. Endocrinol. Metab. 288: E1110-E1119 [Abstract] [Full Text]  
• Lionikas, A., Blizard, D. A., Gerhard, G. S., Vandenbergh, D. J., Stout, J. T., Vogler, G. P., McClearn, G. E., Larsson, L. (2005). Genetic determinants of weight of fast- and slow-twitch skeletal muscle in 500-day-old mice of the C57BL/6J and DBA/2J lineage. Physiol. Genomics 21: 184-192 [Abstract] [Full Text]  
• Bogdanovich, S., Perkins, K. J., Krag, T. O. B., Whittemore, L.-A., Khurana, T. S. (2005). Myostatin propeptide-mediated amelioration of dystrophic pathophysiology. FASEB J. 19: 543-549 [Abstract] [Full Text]  
• Wagner, K. R., Liu, X., Chang, X., Allen, R. E. (2005). Muscle regeneration in the prolonged absence of myostatin. Proc. Natl. Acad. Sci. USA 102: 2519-2524 [Abstract] [Full Text]  
• Varga, L., Pinke, O., Muller, G., Kovacs, B., Korom, E., Szabo, G., Soller, M. (2005). Mapping a Syntenic Modifier on Mouse Chromosome 1 Influencing the Expressivity of the Compact Phenotype in the Myostatin Mutant (MstnCmpt-dl1Abc) Compact Mouse. Genetics 169: 489-493 [Abstract] [Full Text]  
• (2004). Lucina. Arch. Dis. Child. 89: 1182-1182 [Full Text]  
• Catipovic, B., Williams, M. S., Uhlenberg, B., Lucke, B., Schuelke, M. (2004). Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child. NEJM 351: 1030-1031 [Full Text]  
• Sartorelli, V., Fulco, M. (2004). Molecular and Cellular Determinants of Skeletal Muscle Atrophy and Hypertrophy. Sci Signal 2004: re11-re11 [Abstract] [Full Text]