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Previous Volume 350:2711-2712 June 24, 2004 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The activity of the p53 tumor-suppressor protein has a key role in controlling both cancer and aging: underactivity encourages the growth of cancer, and overactivity can accelerate the aging process. In most tumor cells, the p53 protein is inactivated by mutation, whereas in some others its function is blocked in other ways. Restoring the function of p53 to tumor cells is the dream of many investigators,¹ and Snyder and colleagues² show how well this can work by demonstrating that a p53-activating molecule can save the lives of mice carrying very aggressive disseminated cancer. What are the prospects for developing this . . . [Full Text of this Article]

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From the Department of Surgery and Molecular Oncology, University of Dundee, Dundee, United Kingdom.

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