Fifty years ago, the idea that infectious agents caused lymphomawould have seemed heretical. Although viruses were known tocause tumors in animals, they were not considered a cause ofdisease in humans that simply was not what infectionsdid. Rather, tumors were considered to be the consequence ofenvironmental exposures and of inherited genetic abnormalities.This view began to change 35 years ago, when a rare form ofnon-Hodgkin's lymphoma Burkitt's lymphoma wasfound to be closely associated with EpsteinBarr virus(EBV). The relationship between EBV infection and lymphoma,however, was considered to be an anomaly, . . . [Full Text of this Article]
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From the Departments of Medicine and of Health Research and Policy, Stanford University Medical Center, Stanford, Calif. (J.P.); and the Department of Histopathology, Royal Free and University College Medical School, University College London, London (P.G.I.).
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