Fifty years ago, the idea that infectious agents caused lymphomawould have seemed heretical. Although viruses were known tocause tumors in animals, they were not considered a cause ofdisease in humans — that simply was not what infectionsdid. Rather, tumors were considered to be the consequence ofenvironmental exposures and of inherited genetic abnormalities.This view began to change 35 years ago, when a rare form ofnon-Hodgkin's lymphoma — Burkitt's lymphoma — wasfound to be closely associated with Epstein–Barr virus(EBV). The relationship between EBV infection and lymphoma,however, was considered to be an anomaly, . . . [Full Text of this Article]
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From the Departments of Medicine and of Health Research and Policy, Stanford University Medical Center, Stanford, Calif. (J.P.); and the Department of Histopathology, Royal Free and University College Medical School, University College London, London (P.G.I.).
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