The winter of 20032004 will be remembered as a year inwhich stories about influenza dominated the news and patientsyoung and old clamored for influenza vaccination. This intenseinterest is the result of the confluence of multiple circumstances.The onset of the annual influenza epidemic came earlier thanexpected and was accompanied by reports of severe disease inpreviously healthy children, associated with the isolation ofantigenically variant influenzaviruses represented by the prototypicstrain A/Fujian/411/2002 (H3N2). There was concern that theavailable influenza vaccine would not be optimally effectiveagainst this strain of virus, but at the same time, . . . [Full Text of this Article]
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From the Infectious Diseases Unit, University of Rochester Medical Center, Rochester, N.Y.
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