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Previous Volume 350:404-405 January 22, 2004 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In patients with cancer who undergo surgery with curative intent but who are known to be at risk for a recurrence, postoperative chemotherapy increases the chance of a cure. The basis of this adjuvant therapy rests on demonstrations in animal models that the presence of a small residual tumor rather than a large tumor is associated with a greater fraction of tumor cells that are growing, a greater fractional rate of cell death, a lower likelihood that tumor cells are drug resistant, and a higher cure rate. Subsequent clinical investigations have established proof of these principles for adjuvant chemotherapy in . . . [Full Text of this Article]

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From Cancer Centers and Programs, Beth Israel Medical Center; and St. Luke's–Roosevelt Hospital Center — both in New York.

Related Letters:

Adjuvant Chemotherapy for Lung Cancer
Ikhlaque N., Baumann M. A., Büyükçelik A., Utkan G., Yalçin B., Feliu J., Espinosa E., Sánchez J. J., Sauter C., Morgan G. W., Dunant A., Pignon J.-P., Le Chevalier T.
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N Engl J Med 2004; 350:1681-1683, Apr 15, 2004. Correspondence

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