Osteoporosis was originally described in literature and arthundreds of years ago. Our ability to treat this disease laydormant for centuries, but in the past 10 years, clinical trialshave improved treatment options and efficacy. In this issueof the Journal, Meunier et al.1 report on their study of thesafety and effectiveness of strontium ranelate as a putative,novel therapy for osteoporosis.
Strontium was originally detected in lead mines near Strontian,Scotland, in the late 1700s. This earth element is present inwater and food and in trace amounts throughout the skeleton.Although absorption is poor when strontium . . . [Full Text of this Article]
Source Information
From the Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Beirut, Lebanon.
Bruyere, O., Roux, C., Detilleux, J., Slosman, D. O., Spector, T. D., Fardellone, P., Brixen, K., Devogelaer, J.-P., Diaz-Curiel, M., Albanese, C., Kaufman, J.-M., Pors-Nielsen, S., Reginster, J.-Y.
(2007). Relationship between Bone Mineral Density Changes and Fracture Risk Reduction in Patients Treated with Strontium Ranelate. J. Clin. Endocrinol. Metab.
92: 3076-3081
[Abstract][Full Text]
(2006). {blacktriangledown}Strontium ranelate for osteoporosis?. DTB
44: 29-32
[Abstract][Full Text]
D'Haese, P. C., Santacruz, F., De Broe, M. E., Taur, Y., Al-Tureihi, F., Wolf-Klein, G., Meunier, P. J.
(2004). Postmenopausal Osteoporosis and Strontium Ranelate. NEJM
350: 2001-2003
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