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Previous Volume 350:578-585 February 5, 2004 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The Budd–Chiari syndrome is a heterogeneous group of disorders characterized by hepatic venous outflow obstruction at the level of the hepatic venules, the large hepatic veins, the inferior vena cava, or the right atrium.¹ Hepatic veno-occlusive disease refers to obstruction of hepatic venous outflow at the level of the central or sublobular hepatic veins, or both.

Pathogenesis

Obstruction of the hepatic venous outflow tract results in increased hepatic sinusoidal pressure and portal hypertension. In the early stages, portal venous perfusion of the liver is decreased, which may result in portal venous thrombosis.² The ensuing venous stasis and congestion lead to hypoxic . . . [Full Text of this Article]

Clinical Manifestations

Diagnosis

Management

Medical Management

Relief of Hepatic Venous Outflow Tract Obstruction

            Thrombolytic Therapy and Angioplasty

            Transjugular Intrahepatic Portosystemic Shunts

            Surgery

Liver Transplantation

Source Information

From the Advanced Liver Disease Study Group, Division of Gastroenterology and Hepatology and Internal Medicine, Mayo Clinic, Rochester, Minn.

Address reprint requests to Dr. Kamath at the Division of Gastroenterology and Hepatology and Internal Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, or at kamath.patrick@mayo.edu.

Related Letters:

The Budd–Chiari Syndrome
Janssen H. L.A., Garcia-Pagan J.-C., Valla D.-C., Cardenas A., Menon K.V. N., Shah V., Kamath P. S.
Extract | Full Text | PDF  
N Engl J Med 2004; 350:1906-1908, Apr 29, 2004. Correspondence

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