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Previous Volume 350:586-597 February 5, 2004 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Yvonne Cossart, an Australian virologist working in London in the mid-1970s, noted an anomalous reaction of a normal blood donor's serum (occupying position 19 in plate B) in an assay for hepatitis B. When Cossart excised the line of antigen–antibody precipitation, she saw the particles shown in Figure 1A, and in this way discovered a parvovirus in human blood.¹ With the same technique, antibodies to parvovirus B19 were found in a large proportion of normal adults, indicating that infection is common and probably occurs in childhood. A disease was linked to parvovirus B19 infection by John Pattison and colleagues, . . . [Full Text of this Article]

Parvovirus B19 and the Parvoviridae

The Parvovirus Family

Genome, Transcription, and Proteins of Parvovirus B19

Parvovirus B19 Diseases

Epidemiology

Fifth Disease

Arthropathy

Transient Aplastic Crisis

Persistent Parvovirus Infection

Hydrops Fetalis

Other Suspected Parvovirus B19 Syndromes

Pathophysiology

Parvovirus B19 Tropism

Immunity to Parvovirus B19

Clinical Diagnosis

Treatment and Prevention

Specific Therapies

Vaccine Development

Conclusions

Source Information

From the Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.

Address reprint requests to Dr. Young at Bldg. 10, Rm. 7C103, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-1652, or at youngn@nhlbi.nih.gov.

Related Letters:

Parvovirus B19
Bültmann B. D., Sotlar K., Klingel K., Pronovost P. H., Young N. S., Brown K. E.
Extract | Full Text | PDF  
N Engl J Med 2004; 350:2006-2007, May 6, 2004. Correspondence

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