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Clinical Implications of Basic Research
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Volume 350:834-835 February 19, 2004 Number 8
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Ozone — From Environmental Pollutant to Atherogenic Determinant
Joseph Loscalzo, M.D., Ph.D.

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Molecular oxygen (O2) is abundant in the atmosphere and is essential for most forms of life. A study by Wentworth and colleagues has now implicated one of its derivatives in the highly prevalent vascular disorder atherosclerosis.1

Molecular oxygen engages in a variety of metabolic redox reactions that yield a range of products collectively termed "reactive oxygen species." The addition of one electron converts molecular oxygen to superoxide anion (O2–•), whereas the addition of two electrons yields hydrogen peroxide (H2O2). Hydrogen peroxide, in turn, can react with ferrous iron (Fe2+) to produce the highly reactive hydroxyl . . . [Full Text of this Article]


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From Boston University School of Medicine, Boston.


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