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Volume 350:943-945 February 26, 2004 Number 9
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Valsartan, Captopril, or Both in Myocardial Infarction

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 by Pfeffer, M. A.
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To the Editor: In their assessment of treatment with valsartan, captopril, or both in patients with myocardial infarction complicated by heart failure or left ventricular dysfunction (Nov. 13 issue),1 Pfeffer et al. calculate a hazard ratio for their patients by using an "imputed placebo." Because they include this hazard ratio in a figure with hazard ratios from other trials that were placebo-controlled (Figure 3 of the article), the message is conveyed — since figures are powerful — that this trial was also placebo-controlled. It was not. Two references supporting this depiction are provided in the article.2,3 These, and a subsequent . . . [Full Text of this Article]




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