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Previous Volume 351:1053-1056 September 9, 2004 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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All drugs have the potential to cause adverse effects. Occasionally, serious adverse effects are not identified in preclinical studies and become apparent only when a drug is in widespread clinical use — a particular problem with adverse events that are rare and result in few symptoms. One example of relevance to clinicians and regulatory agencies is drug-induced prolongation of the QT interval. During the past few years, many drugs have been removed from the market or required to include "black box" warnings on their labels because of the potential for QT-interval prolongation. The list of causative medications is daunting, and . . . [Full Text of this Article]

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From the Department of Medicine, University of Toronto (B.A.L., D.N.J.); and the Divisions of Geriatric Medicine (B.A.L.), General Internal Medicine (D.N.J.), and Clinical Pharmacology (B.A.L., D.N.J.), Sunnybrook and Women's College Health Sciences Centre — both in Toronto.

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Oral Erythromycin and the Risk of Sudden Death
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N Engl J Med 2005; 352:301-304, Jan 20, 2005. Correspondence

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