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Clinical Implications of Basic Research
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Volume 351:1455-1457 September 30, 2004 Number 14
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Chitin Checking — Novel Insights into Asthma
Marsha Wills-Karp, Ph.D., and Christopher L. Karp, M.D.

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Westernized countries are in the midst of an asthma epidemic. Despite much effort, therapeutic advances have not kept pace with the dramatic increases in the incidence, prevalence, and severity of allergic asthma that have occurred over the past two decades in such countries. A recent study by Zhu et al. provides new and unexpected insight into the pathogenesis of allergic asthma that could fuel the development of new therapies.1

Allergic asthma is thought to result from maladaptive inflammatory responses to ubiquitous environmental proteins in genetically susceptible persons. More specifically, allergic asthma is a chronic inflammatory disorder of the airways mediated . . . [Full Text of this Article]


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From the Divisions of Immunobiology and Molecular Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati.


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