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Correspondence
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Volume 351:1459-1461 September 30, 2004 Number 14
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Airway Obstruction in Chronic Obstructive Pulmonary Disease

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by Barnes, P. J.
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by Hogg, J. C.
-PubMed Citation
To the Editor: In their article on small-airway obstruction in patients with chronic obstructive pulmonary disease (COPD), Hogg and colleagues (June 24 issue)1 report that the progression of COPD is associated with the luminal accumulation of exudates and inflammatory-cell infiltration. However, the role of hypersecretion and retention of mucus in airway narrowing has not been addressed in detail. Retention of mucus is likely to lead to a major debilitating symptom of COPD. No specific therapy is available to date,2 but a new molecular treatment option that inhibits mucus matrix-forming protein mucin 5AC has recently been proposed.3 Mucin 5AC is present . . . [Full Text of this Article]



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