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Previous Volume 351:1577 October 7, 2004 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Although the appearance of the blood smear presented by Fairhurst and Casella (June 24 issue)¹ is consistent with the presence of hemoglobin C disease, the extremely low mean corpuscular volume and the clinical scenario are more consistent with the presence of hemoglobin C -thalassemia. Hemoglobin C -thalassemia is common in African populations, and the clinical disorder is usually mild; features include low-grade anemia, a low mean corpuscular volume, and minimal elevation of the reticulocyte count, without splenomegaly. The blood smear is indistinguishable from that in hemoglobin C disease and shows microspherocytes and target cells.² The electrophoretic pattern . . . [Full Text of this Article]

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