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Previous Volume 351:1577-1579 October 7, 2004 Number 15 Next

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To the Editor: The hot flash is one of the most commonly encountered symptoms of menopause, yet there is little understanding of its underlying physiology. With its unpredictable onset and evanescent nature, this troubling symptom has been difficult to study. The peripheral vasodilatation and rise in skin temperature are readily apparent, but what else happens during a hot flash?

A 46-year-old, hypertensive, black woman was participating in a study in which we were examining the relationship of sleep and stress to hypertension. On enrolling in the study, she reported having menopausal symptoms, including hot flashes.

A continuous beat-to-beat blood-pressure recording . . . [Full Text of this Article]

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