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Previous Volume 351:1645-1654 October 14, 2004 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Prosthetic-joint replacement is used increasingly to alleviate pain and to improve mobility. Infections associated with prosthetic joints cause significant morbidity and account for a substantial proportion of health care expenditures.^1,2 The use of perioperative antimicrobial prophylaxis and a laminar airflow surgical environment has reduced the risk of intraoperative infection to less than 1 percent after hip and shoulder replacement and to less than 2 percent after knee replacement.^3,4,5 Whereas the management of native-joint infection and osteomyelitis is well established,^6,7 the management of infection associated with prosthetic joints is less standardized, because of the variable clinical presentations and the lack of . . . [Full Text of this Article]

Pathogenesis

Role of Biofilm

Interaction among Microbial, Host, and Prosthetic Factors

Clinical Presentation

Diagnosis

Laboratory Studies

Histopathological Studies

Microbiologic Studies

Imaging Studies

Treatment

Medical Therapy

Surgical Therapy

Treatment Algorithm

Prevention

Outlook

Conclusions

Source Information

From the Basel University Medical Clinic, Liestal, Switzerland (W.Z.); the Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn. (A.T.); and the Clinic of Orthopedic Surgery, Kantonsspital, Liestal, Switzerland (P.E.O.).

Address reprint requests to Dr. Zimmerli at the University Medical Clinic, Kantonsspital, CH-4410 Liestal, Switzerland, or at werner.zimmerli@unibas.ch.

Related Letters:

Prosthetic-Joint Infections
Glatt A. E., Melamed E., Cohen I., Robinson D., Zimmerli W., Trampuz A.
Extract | Full Text | PDF  
N Engl J Med 2005; 352:95-97, Jan 6, 2005. Correspondence

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