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Editorial
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Volume 351:1792-1794 October 21, 2004 Number 17
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Adjunctive Steroids for Tuberculous Meningitis — More Evidence, More Questions
Vincent Quagliarello, M.D.

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 by Thwaites, G. E.
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Tuberculosis continues to plague global health. The World Health Organization (WHO) has estimated an annual incidence of 8.8 million cases of tuberculosis worldwide, with 1.8 million deaths. Most of the disease burden is in Africa and Southeast Asia, where the annual incidence rates are 350 and 182 cases per 100,000 population, respectively.1

Of the 22 "high-burden" countries that account for 80 percent of the world's estimated incidence, only Vietnam has met the WHO targets for both case detection (70 percent) and treatment success (85 percent). Despite nationwide use of directly observed therapy, a low prevalence of coinfection with the human . . . [Full Text of this Article]


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From Yale University School of Medicine, New Haven, Conn.


Related Letters:

Dexamethasone for Tuberculous Meningitis
Seligman S. J., Vagenakis A. G., Kyriazopoulou V., Marras T. K., Thwaites G. E., Quy H. T., Farrar J. J., Quagliarello V.
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N Engl J Med 2005; 352:628-630, Feb 10, 2005. Correspondence

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