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Volume 351:1800-1802 October 21, 2004 Number 17
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PSA Velocity and Prostate Cancer

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by D'Amico, A. V.
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To the Editor: There are some basic methodologic flaws in the work by D'Amico et al. (July 8 issue).1 In their multivariate analyses, the prostate-specific antigen (PSA) velocity was modeled as a binary variable on the basis of a threshold of 2.0 ng per milliliter per year. This threshold was selected on the basis of a univariate analysis of the same data, and hence the P values for all the multivariate analyses are overly optimistic. The multivariate analyses are central to the report, since they are the basis for claims that the PSA velocity provides prognostic information beyond that provided . . . [Full Text of this Article]



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