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Previous Volume 351:1911-1913 October 28, 2004 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In his review article on Alzheimer's disease (July 1 issue),¹ Cummings states that there is "increasing consensus" that the production of beta-amyloid (A) peptide is "central to the pathogenesis of Alzheimer's disease." He neglects to mention that there are also data showing that despite massive A accumulation in the brains of animals and humans, there is little associated cell death. Indeed, our work suggests that there is only a weak correlation between A and cognitive decline and that deposition of A is not the earliest neuropathologic event observed in the brains of persons with Alzheimer's disease . . . [Full Text of this Article]

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