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Previous Volume 351:1937-1940 November 4, 2004 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Although Parkinson's disease was once considered a purely sporadic disease, recent advances in molecular genetics have revealed important genetic influences underlying the development of the disorder. Eight defined genetic loci are now associated with highly penetrant autosomal dominant or recessive Parkinson's disease (see Table).^1,2 Causative mutations have been identified in five genes, and the ensuing molecular insights have led to substantial advances in our understanding of the pathogenesis of the disease and in experimental approaches to the study of the disorder.

View this table: [in this window] [in a new window]   Table. Genetic Loci Implicated in Parkinson's Disease.

 
The first protein implicated in familial Parkinson's disease was -synuclein, an abundant . . . [Full Text of this Article]

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From the Department of Pathology, Division of Neuropathology, Brigham and Women's Hospital and Harvard Medical School, Boston.

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