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Previous Volume 351:159-169 July 8, 2004 Number 2 Next

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Acute renal failure occurs in approximately 19 percent of patients with moderate sepsis, 23 percent with severe sepsis, and 51 percent with septic shock when blood cultures are positive (Table 1 and Table 2).^1,2 A progressive increase in the acute respiratory distress syndrome also occurs with moderate and severe sepsis and septic shock. In the United States, an estimated 700,000 cases of sepsis occur each year, resulting in more than 210,000 deaths; this number accounts for 10 percent of all deaths annually and exceeds the number of deaths due to myocardial infarction.³ The combination of acute renal failure . . . [Full Text of this Article]

Hemodynamics and Hormones

The Pressor Effect of Arginine Vasopressin

Effects of Systemic Arterial Vasodilatation on Body-Fluid Volume and Starling Forces

Experimental Models of Endotoxemia and Sepsis

Vasoactive Hormones

Endothelial and Inducible Nitric Oxide Synthases

Endotoxemia

            Tumor Necrosis Factor and Reactive Oxygen Species

            Nonspecific Inhibitors of Nitric Oxide Synthase

            Cytokines, Chemokines, and Adhesion Molecules

Disseminated Intravascular Coagulation

Early Resuscitation

Hyperglycemia and Insulin

Glucocorticoids and Mechanical Ventilation

Renal Replacement

Conclusions

Source Information

From the Department of Medicine, University of Colorado Health Sciences Center, Denver.

Address reprint requests to Dr. Schrier at the Department of Medicine, University of Colorado Health Sciences Center, 4200 E. 9th Ave., Box C-281, Denver, CO 80262, or at robert.schrier@uchsc.edu.

Related Letters:

Acute Renal Failure and Sepsis
Bellomo R., May C., Wan L., Jackson W. L. Jr., Heresi G. A., Haddy F. J., Schrier R. W., Wang W.
Extract | Full Text | PDF  
N Engl J Med 2004; 351:2347-2349, Nov 25, 2004. Correspondence

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