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Case Records of the Massachusetts General Hospital
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Volume 351:171-178 July 8, 2004 Number 2
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Case 21-2004 — A 63-Year-Old Man with Metastatic Prostate Carcinoma Refractory to Hormone Therapy
Donald S. Kaufman, M.D., W. Scott McDougal, M.D., Anthony L. Zietman, M.D., Mukesh G. Harisinghani, M.D., and Robert H. Young, M.D.

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Presentation of Case

A 63-year-old man was evaluated in the clinic because of metastatic prostate cancer that was no longer responding to hormone therapy.

The patient had been well until eight years before he came to the clinic, when he had noticed a decreased urinary stream and urinary hesitancy. A test for prostate-specific antigen (PSA) six months later showed a level of 2.7 ng per milliliter; six months after that, the PSA level was 7.7 ng per milliliter. A transrectal needle biopsy of the prostate showed adenocarcinoma, Gleason grade 3 to 4 (on a scale of 1 to 5, with 1 indicating low-grade . . . [Full Text of this Article]

Discussion of Management

Management of Localized Prostate Cancer

            Radical Prostatectomy

            Radiation Therapy

Management of Locally Advanced Prostate Cancer

            Radiation Therapy

            Hormonal Therapy

            Chemotherapy

Anatomical Diagnosis


Source Information

From the Division of Medical Oncology, Department of Medicine (D.S.K.), and the Departments of Urology (W.S.M.), Radiation Oncology (A.L.Z.), Radiology (M.G.H.), and Pathology (R.H.Y.), Massachusetts General Hospital; and the Departments of Medicine (D.S.K.), Urology (W.S.M.), Radiation Oncology (A.L.Z.), Radiology (M.G.H.), and Pathology (R.H.Y.), Harvard Medical School.


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