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Clinical Implications of Basic Research
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Volume 351:185-187 July 8, 2004 Number 2
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Sparking the Failing Heart
Maryjane A. Farr, M.D., and Craig T. Basson, M.D., Ph.D.

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Despite advances in the management of congestive heart failure (CHF), most patients with advanced forms die within a year after receiving the diagnosis. Half of all deaths from CHF are caused by ventricular tachycardia, and about 80 percent of patients with symptomatic systolic dysfunction have ventricular tachycardia. Ischemia and myocardial scars are major determinants of the risk of ventricular tachycardia, along with some CHF therapies themselves — for example, inotropic agents such as milrinone and dobutamine. Other available medications include beta-blockers, agents that block the renin–angiotensin–aldosterone pathway, vasodilators, diuretics, and natriuretics. A new study by Wehrens et al.1 points to . . . [Full Text of this Article]


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From the Molecular Cardiology Laboratory and Congestive Heart Failure Center, Greenberg Cardiology Division, Department of Medicine, Weill Medical College of Cornell University, New York.


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