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Correspondence
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Volume 351:190-192 July 8, 2004 Number 2
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Ten Years of Alendronate Treatment for Osteoporosis in Postmenopausal Women

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 by Bone, H. G.
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To the Editor: In their report on 10 years of alendronate therapy for osteoporosis in postmenopausal women, Bone et al. (March 18 issue)1 mention the long retention time of alendronate in bone as an advantage. This view is based on the fact that the large reduction in bone turnover is present five years after the discontinuation of treatment. The authors claim that histomorphometric analysis confirmed long-term bone safety,2,3 but the study they cite followed treatment for only two to three years in a small group of patients receiving 20 mg of alendronate.2 What the present study actually shows is that . . . [Full Text of this Article]


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