FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 351:195-196 July 8, 2004 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Roodman, G. D. PubMed Citation

To the Editor: Roodman (April 15 issue)¹ stated that in osteolytic metastases, the destruction of bone is mediated by osteoclasts rather than tumor cells, whereas the mechanisms of osteoblastic metastases and the factors involved are unknown. It would be helpful if he would put these new concepts into perspective in relation to traditional observations.

Is there no place for the conventional view that metastases can cause osseous destruction simply because of tumor replacement of bone, as appears to happen in metastases to other tissues, such as the liver, or at the primary tumor site? This view is in keeping with . . . [Full Text of this Article]

This article has been cited by other articles:

• Hall, F. M., Uematsu, T. (2005). Imaging Bone Metastases in Breast Cancer. Am. J. Roentgenol. 185: 1082-1083 [Full Text]