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Previous Volume 351:2124-2125 November 11, 2004 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Cachexia is a condition associated with a variety of serious diseases, including cancer, AIDS, and congestive heart failure. It is manifested as weight loss involving both adipose tissue and skeletal muscle. Wasting is not due to malnutrition, which preferentially depletes lipids from adipose tissue, but involves a complex disruption of several systems that also leads to anemia, insulin resistance, immunosuppression, and activation of an acute-phase response. The resulting progressive weakness can make patients with cancer more susceptible to the toxic effects of radiation and chemotherapy; many such patients die from cachexia-related syndromes, rather than from their tumors. Knowledge of the . . . [Full Text of this Article]

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From the Departments of Neurology, Medicine, and Biochemistry and the Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Washington School of Medicine, Seattle.

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