Considerable clinical heterogeneity and wide variation in survivalamong patients are characteristic of many B-cell lymphomas.Prognostic markers that predict the clinical behavior of suchtumors with greater accuracy than is currently possible areurgently needed to permit management decisions based on theprognosis in individual cases. Moreover, the variable courseof some types of B-cell lymphomas may indicate that they areactually a mixture of distinct cancers that are not distinguishedby the current classification schemes. In recent years, severallarge-scale studies involving microarray-based gene-expressionprofiling have identified novel lymphoma subtypes and improvedthe accuracy of predictions of outcome. . . . [Full Text of this Article]
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From the Institute for Cell Biology (Tumor Research), University of DuisburgEssen Medical School, Essen, Germany.
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