FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 351:2236-2237 November 18, 2004 Number 21 Next

C/EBP in Asthma

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Roth, M. PubMed Citation

To the Editor: Roth et al. (Aug. 5 issue)¹ report that glucocorticoids do not inhibit the proliferation of bronchial smooth-muscle cells from patients with asthma and propose that these cells lack expression of the CCAAT/enhancer binding protein (C/EBP), a transcription factor. However, Figure 4A in their article shows reactivity of an anti-C/EBP antibody to a protein band about 4 kD below what is seen for patients with emphysema. This raises the possibility that a different isoform of C/EBP is expressed, possibly as a result of alternate RNA splicing, aberrant glycosylation, or up-regulation of a cleavage enzyme of C/EBP. . . . [Full Text of this Article]

This article has been cited by other articles:

• Warner, E., Jong, R., Plewes, D., Yaffe, M., Narod, S. (2005). Surveillance of BRCA1 and BRCA2 Carriers--Reply. JAMA 293: 931-931 [Full Text]