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Previous Volume 351:2343 November 25, 2004 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Perturbations in nutritional status disrupt the complex interplay of gonadotropins and gonadal hormones that are critical for ovulation and fertility. At a teleologic level, anovulation in extremely lean women would be an appropriate compensatory mechanism to avoid the excess metabolic demands imposed by reproduction at a time when nutrient intake is insufficient.

In the study by Welt et al. (Sept. 2 issue),¹ the administration of leptin was associated with an ovulatory menstrual cycle in three of eight subjects. Before therapy, these eight subjects had a mean (±SD) body-mass index (the weight in kilograms divided by the square . . . [Full Text of this Article]

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