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Correspondence
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Volume 351:2344-2345 November 25, 2004 Number 22
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Methylprednisolone, Valacyclovir, or Both for Vestibular Neuritis

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by Strupp, M.
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To the Editor: With respect to the report by Strupp et al. (July 22 issue),1 we wonder about the possible effect of the exclusion of 20 percent of the participants because of the lack of primary efficacy data. In addition, the rationale for the reported regimen of methylprednisolone is unclear. Why would a course of 22 days be any better than a 1-week course, which would be much simpler and encourage better compliance? Finally, we question the appropriateness of using vestibular paresis, a surrogate outcome, as a primary efficacy measure, since results from previous studies suggest that improvement in vestibular . . . [Full Text of this Article]



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