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Correspondence
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Volume 351:2451-2452 December 2, 2004 Number 23
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Venous Thrombosis in Children

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 by Goldenberg, N. A.
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To the Editor: Goldenberg et al. (Sept. 9 issue)1 report interesting data about the usefulness of the D-dimer test to predict outcomes in children after a first thromboembolic event. In children, 95 percent of venous thromboembolic events are secondary to underlying disorders associated with hypercoagulable states: cancer, trauma or surgery, congenital heart disease, and systemic lupus erythematosus.2,3,4 One may expect that the great majority of these children will have persistently abnormal D-dimer levels. Therefore, the clinical usefulness of D-dimer testing in everyday practice to predict the risk of an adverse outcome or a recurrence might be limited to the minority . . . [Full Text of this Article]


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