Epithelial cancer of the ovary is a relatively uncommon gynecologiccancer in the United States, with approximately 25,580 new casesand 16,090 deaths anticipated in 2004.1 Most patients presentwith advanced disease, which is managed with surgical resectionfollowed by platinum-based chemotherapy. During the past decade,advances in chemotherapy have resulted in improved survivaland in more effective treatment of relapsed disease. In addition,a better understanding of genetic risk factors has permitteda tailored approach to preventive strategies, such as bilateralsalpingo-oophorectomy in selected women. This review describesthe clinical features of epithelial ovarian cancer, with anemphasis on . . . [Full Text of this Article]
Epidemiology and Risk Factors
Familial Syndromes
Prophylactic Treatment for Women with Germ-Line Mutations in BRCA1 or BRCA2
Clinical Presentation
Surgery
Postoperative Chemotherapy
Early-Stage Disease
Advanced Disease
Management of Recurrent Disease
Prospects for a Brighter Future
Source Information
From the Program of Gynecologic Medical Oncology, Beth Israel Deaconess Medical Center, Boston.
Address reprint requests to Dr. Cannistra at the Program of Gynecologic Medical Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, or at scannist@bidmc.harvard.edu.
Related Letters:
Cancer of the Ovary
Matulonis U., Abrahm J. L., Liu C.-M., Cannistra S. A.
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N Engl J Med 2005;
352:1268-1269, Mar 24, 2005.
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