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Volume 351:2556-2558 December 9, 2004 Number 24
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Mutation of Perinatal Myosin Heavy Chain

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 by Veugelers, M.
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To the Editor: Veugelers et al. (July 29 issue)1 report on patients with the trismus–pseudocamptodactyly syndrome as having a "Carney complex variant." Among more than 500 patients with the Carney complex in our database, there are none with the trismus–pseudocamptodactyly syndrome.2,3

In our analysis of patients reported to have the trismus–pseudocamptodactyly syndrome, we identified several with freckling. These patients appeared to have a familial disorder at variance with the Carney complex — not a simple Carney complex variant. The dictionary definition of variant is "varying usually slightly from the standard form." By contrast, patients with the trismus–pseudo-camptodactyly syndrome have none . . . [Full Text of this Article]




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