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Volume 351:2655-2657 December 16, 2004 Number 25
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Glucocorticoids and Bone Mineral Content in the Childhood Nephrotic Syndrome

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by Leonard, M. B.
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To the Editor: Leonard et al. (Aug. 26 issue)1 report that the use of glucocorticoids does not appear to be associated with deficits in bone mineral content in children with the nephrotic syndrome — results that differ from ours.2 An important observation was a lower bone mineral content at the spine after correction for the body-mass index. The earliest changes of glucocorticoid-induced bone loss are indeed seen in the lumbar spine because of its high bone mineral content. We would also be interested to know the correlation between the bone mineral content and glucocorticoid dose, since doses varied widely. There . . . [Full Text of this Article]



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