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Previous Volume 351:2761-2766 December 23, 2004 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Historical Perspective

On December 23, 1954, a surgical team at the Peter Bent Brigham Hospital in Boston, under the direction of Joseph Murray, removed a kidney from a healthy donor and transplanted it into his identical twin, who had chronic glomerulonephritis and was being sustained on the newly modified Kolff–Brigham artificial kidney machine.¹ The organ functioned immediately,² and the recipient survived for nine years, at which time his allograft failed from recurrent glomerulonephritis. The donor has survived for 50 years. Other historical details are provided by Morris elsewhere in this issue of the Journal.³ This first organ transplantation was not an . . . [Full Text of this Article]

Progress and Challenges

Chronic Allograft Dysfunction

Long-Term Need for Immunosuppression

Medical Complications

Organ Shortage

Summary

Source Information

From the Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, and Harvard Medical School, Boston.

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