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A correction has been published: N Engl J Med 2005;352(7):740.

Previous Volume 351:2832-2838 December 30, 2004 Number 27 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations.

A 25-year-old registered nurse comes for a visit to initiate prenatal care after receiving a positive result on a pregnancy test. On review of her vaccination status, she reports that she declined hepatitis B vaccination when it was offered by her current employer, since she does not draw blood and thus does not consider herself at risk for infection. Should she receive . . . [Full Text of this Article]

The Clinical Problem

Hepatitis B Virus and Infection

Epidemiology

Sources of Infection and Transmission

Strategies and Evidence

Hepatitis B Vaccine

Administration of Vaccine

Vaccine Immunogenicity

Lack of Response

Safety

Hepatitis B Immune Globulin

Maternal Screening for Hepatitis B

Areas of Uncertainty and Concern

Guidelines

Summary and Recommendations

Source Information

From the Mayo Vaccine Research Group (G.A.P., R.M.J.), the Program in Translational Immunovirology and Biodefense (G.A.P.), the Department of Internal Medicine (G.A.P.), and the Department of Pediatric and Adolescent Medicine (R.M.J.), Mayo Clinic, Rochester, Minn.

Address reprint requests to Dr. Poland at the Mayo Vaccine Research Group, Mayo Clinic and Foundation, 611C Guggenheim Bldg., 200 First St. SW, Rochester, MN 55905, or at poland.gregory@mayo.edu.

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