During the past two decades, molecular biologists have beendissecting the heterogeneity of human cancer a diversitythat oncologists have long appreciated, especially because patientswho have similar stages and grades of cancer and whose tumorshave similar histologic features have a broad range of clinicaloutcomes. Some cancers respond to treatment; others do not.Some patients have a recurrence of cancer; others are cured.
Molecular markers promise the ability to estimate prognosesand predict responses to particular treatments with greaterprecision than is possible with clinical findings. With furtherrefinement of molecular diagnostics, the care of patients with. . . [Full Text of this Article]
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From the Departments of Experimental Therapeutics (R.C.B.) and Breast Medical Oncology (G.N.H.), University of Texas M.D. Anderson Cancer Center, Houston.
Ellis, M. J., Tao, Y., Luo, J., A'Hern, R., Evans, D. B., Bhatnagar, A. S., Chaudri Ross, H. A., von Kameke, A., Miller, W. R., Smith, I., Eiermann, W., Dowsett, M.
(2008). Outcome Prediction for Estrogen Receptor-Positive Breast Cancer Based on Postneoadjuvant Endocrine Therapy Tumor Characteristics. JNCI J Natl Cancer Inst
100: 1380-1388
[Abstract][Full Text]
Chen, H.-Y., Yu, S.-L., Chen, C.-H., Chang, G.-C., Chen, C.-Y., Yuan, A., Cheng, C.-L., Wang, C.-H., Terng, H.-J., Kao, S.-F., Chan, W.-K., Li, H.-N., Liu, C.-C., Singh, S., Chen, W. J., Chen, J. J.W., Yang, P.-C.
(2007). A Five-Gene Signature and Clinical Outcome in Non-Small-Cell Lung Cancer. NEJM
356: 11-20
[Abstract][Full Text]
Travis, L. B., Rabkin, C. S., Brown, L. M., Allan, J. M., Alter, B. P., Ambrosone, C. B., Begg, C. B., Caporaso, N., Chanock, S., DeMichele, A., Figg, W. D., Gospodarowicz, M. K., Hall, E. J., Hisada, M., Inskip, P., Kleinerman, R., Little, J. B., Malkin, D., Ng, A. K., Offit, K., Pui, C.-H., Robison, L. L., Rothman, N., Shields, P. G., Strong, L., Taniguchi, T., Tucker, M. A., Greene, M. H.
(2006). Cancer Survivorship--Genetic Susceptibility and Second Primary Cancers: Research Strategies and Recommendations. JNCI J Natl Cancer Inst
98: 15-25
[Abstract][Full Text]
Insel, T. R., Quirion, R.
(2005). Psychiatry as a Clinical Neuroscience Discipline. JAMA
294: 2221-2224
[Full Text]
Geradts, J., Goodson, W. H. III, Tang, C. G., Lin, A. Y., Tanvetyanon, T., Paik, S., Wolmark, N., Shak, S., Bast, R. C. Jr., Hortobagyi, G. N.
(2005). Molecular Prediction of Recurrence of Breast Cancer. NEJM
352: 1605-1607
[Full Text]
(2005). Predicting Breast Cancer Recurrence with a Multigene Assay. JWatch Women's Health
2005: 4-4
[Full Text]