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Previous Volume 351:389-391 July 22, 2004 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In 1967, Ashbaugh et al.¹ introduced the use of positive end-expiratory pressure (PEEP) during mechanical ventilation to treat refractory hypoxemia in patients with the acute respiratory distress syndrome (ARDS). Almost 40 years later, the question of how much PEEP is enough remains relevant. Controversy regarding the optimal level of PEEP has persisted despite years of investigation into this question. An increase in our understanding of the pathophysiology of ARDS and ventilator-induced lung injury has led to a renewed interest in the debate.

Studies in animals,^2,3,4 designed to illuminate the cause of ventilator-induced lung injury, show that two primary mechanistic factors . . . [Full Text of this Article]

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From the Brown University School of Medicine and Rhode Island Hospital — both in Providence.

Related Letters:

High versus Low PEEP in ARDS
Perren A., Rotta A. T., Brower R., Morris A., MacIntyre N., the National Heart, Lung and Blood Institute ARDS Clinical Trials Network , Levy M. M.
Extract | Full Text | PDF  
N Engl J Med 2004; 351:2128-2129, Nov 11, 2004. Correspondence

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