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Previous Volume 351:391-392 July 22, 2004 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Perspective by Schrag, D. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Cunningham, D. PubMed Citation

Epidermal growth factor receptor (EGFR) is a member of the HER family of tyrosine kinase cell-surface receptors that are dysregulated in many types of tumor; its expression has been associated with a poor prognosis in colon cancer.¹ There are at least two opportunities to interfere with EGFR signaling that are being exploited clinically.² In one approach, the extracellular receptor domain is bound by antibodies, such as cetuximab, that block ligand-mediated dimerization and subsequent activation of the receptor. In the second, the tyrosine kinase domain is bound by drugs that inhibit phosphorylation, such as gefitinib and erlotinib.

Irinotecan is a topoisomerase . . . [Full Text of this Article]

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From the Mayo Clinic, Rochester, Minn.

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