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Previous Volume 351:393-394 July 22, 2004 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Apoptosis is an amazing thing. By endowing cells with the ability to kill themselves, nature allows entire organisms to be spared at the expense of a few dysfunctional, damaged, or malignant cells. But this strategy comes at a price — mechanisms must exist to keep the apoptotic machinery inactive under normal conditions and quickly activate it when the cell must die. New work by Sun and colleagues¹ reveals that the switch to rapid and efficient cell death unexpectedly involves the destruction of the highest-profile protease within the cell — the 26S proteasome.

Without a doubt, proteolysis is one of the . . . [Full Text of this Article]

Source Information

From Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.

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