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Correspondence
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Volume 351:506-507 July 29, 2004 Number 5
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Cord-Blood Transplants from Unrelated Donors in Hurler's Syndrome

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by Staba, S. L.
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To the Editor: Staba et al. (May 6 issue)1 show the feasibility of cord-blood transplantation for Hurler's syndrome. The high rate of engraftment in their study is greater than one might expect. Allogeneic transplantation for Hurler's syndrome is associated with a high rate of engraftment failure, ranging from 15 to 37 percent.2,3 Transplantation of umbilical cord blood also carries a high risk of graft rejection. Furthermore, studies of the use of reduced-intensity allogeneic stem-cell transplants from unrelated donors suggest that antithymocyte globulin, which has observable effects on T cells for four days,4 might deplete donor-derived T cells and thus contribute . . . [Full Text of this Article]



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