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Previous Volume 351:683-694 August 12, 2004 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Von Willebrand's disease is an inherited bleeding disorder with a prevalence as high as 1 to 2 percent in the general population, according to screening studies.^1,2 In contrast, estimates based on referral for symptoms of bleeding suggest a prevalence of 30 to 100 cases per million, which is similar to the prevalence of hemophilia A.^1,2 The disease was first described in 1926 by the Finnish pediatrician Erik von Willebrand, who used a rowboat to make house calls to patients with the disease in the Åland archipelago. The disease is caused by the quantitative deficiency or dysfunction of von Willebrand factor, . . . [Full Text of this Article]

Classification

Laboratory Diagnosis

General Principles of Treatment

Autologous Replacement Therapy

Dosage and Routes of Administration

Clinical Efficacy

Response and Phenotypes

Adverse Effects

Allogeneic Replacement Therapy

Replacement Products

Dosage of Concentrate

Laboratory Monitoring

Antifibrinolytic Amino Acids

Reproductive Health

Menorrhagia

Management of Delivery

Alloantibodies

Acquired von Willebrand Syndrome

The Future

Conclusions

Source Information

From the Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and the Department of Internal Medicine and Dermatology, Istituto di Ricovero e Cura a Carattere Scientifico Maggiore Hospital and the University of Milan, Milan.

Address reprint requests to Dr. Mannucci at Via Pace 9, 20122 Milan, Italy, or at piermannuccio.mannucci@unimi.it.

Related Letters:

Treatment of von Willebrand's Disease
Kashyap A. S., Anand K. P., Kashyap S., Tanvetyanon T., Mannucci P.M.
Extract | Full Text | PDF  
N Engl J Med 2004; 351:2345-2346, Nov 25, 2004. Correspondence

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