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A correction has been published: N Engl J Med 2004;351(15):1582.

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Volume 351:748-750 August 19, 2004 Number 8
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Female Development — All by Default?
Ieuan A. Hughes, M.D.

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by Biason-Lauber, A.
-PubMed Citation
It has been an indisputable fact that the constitutive sex in mammalian fetal development is female. Furthermore, a functioning ovary is not required for the female phenotype, whereas a testis is mandatory for male development. More than 50 years after Jost performed experiments in rabbit embryos in which castration was followed by testis engraftment, his observations remain a beacon of clarity illuminating the mechanism of fetal sexual differentiation — the physical phenotype consistent with male or female sex.1

Another indisputable fact of mammalian fetal sexual development is the morphogenesis of a bipotential gonad in the genital ridge, dual internal genital . . . [Full Text of this Article]


Source Information

From the Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom.



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