FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 351:824-826 August 19, 2004 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Cristofanilli, M. PubMed Citation

When Steven Paget published his theory of "seed and soil" in 1889,¹ the idea of hematogenous tumor-cell dissemination was born. More than a century later, with the use of molecular tools, new clinical findings have resulted in explanations of hither-to unexplainable phenomena, such as that donor-derived cancer in recipient organ allografts² and viable single tumor cells in secondary organs were both the descendants of a known primary tumor³ and the potential precursors of subsequent metastasis.⁴ Now, as shown by Cristofanilli et al.⁵ in this issue of the Journal, a laboratory assay of circulating tumor cells enables us to predict a . . . [Full Text of this Article]

Source Information

From the Department of Gynecology and Obstetrics and the Breast Health Center, Innsbruck Medical University, Innsbruck, Austria.

This article has been cited by other articles:

• Schiller, J. H. (2008). Noninvasive Monitoring of Tumors. NEJM 359: 418-420 [Full Text]  
• Maheswaran, S., Sequist, L. V., Nagrath, S., Ulkus, L., Brannigan, B., Collura, C. V., Inserra, E., Diederichs, S., Iafrate, A. J., Bell, D. W., Digumarthy, S., Muzikansky, A., Irimia, D., Settleman, J., Tompkins, R. G., Lynch, T. J., Toner, M., Haber, D. A. (2008). Detection of Mutations in EGFR in Circulating Lung-Cancer Cells. NEJM 359: 366-377 [Abstract] [Full Text]  
• Muller, V., Stahmann, N., Riethdorf, S., Rau, T., Zabel, T., Goetz, A., Janicke, F., Pantel, K. (2005). Circulating Tumor Cells in Breast Cancer: Correlation to Bone Marrow Micrometastases, Heterogeneous Response to Systemic Therapy and Low Proliferative Activity. Clin. Cancer Res. 11: 3678-3685 [Abstract] [Full Text]