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Previous Volume 352:48-62 January 6, 2005 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Metabolic complications, including dyslipidemia, insulin resistance, and altered fat distribution (loss of subcutaneous fat and a relative increase in central fat), are common in adults infected with the human immunodeficiency virus (HIV) who are receiving highly active antiretroviral therapy (HAART). These complications may increase these patients' risk of cardiovascular disease. In this review, we discuss progress in the understanding of pathogenetic mechanisms of cardiovascular risk in this population and the development of treatment strategies.

Body-Fat Abnormalities

Abnormalities in body composition have been reported in 40 to 50 percent of ambulatory HIV-infected patients^1,2,3; the proportion is greater in those receiving combination antiretroviral . . . [Full Text of this Article]

Risk Factors and Pathogenesis

Assessment

Dyslipidemia

Prevalence

Pathogenesis

Assessment

Insulin Resistance and Abnormal Glucose Homeostasis

Epidemiology

Pathogenesis

Assessment

Cardiovascular Disease

Epidemiology

Mechanisms of Cardiovascular Disease

Risk Assessment and Treatment Options

Risk-Factor Modification

Lifestyle Modifications

Metabolic Interventions

            Lipid-Lowering Drugs

            Insulin-Sensitizing Drugs

            Growth Hormone

Surgery and Other Strategies to Restore Body Contours

Changes in Antiretroviral Therapy

Prevention

Conclusions

Source Information

From the Program in Nutritional Metabolism and the Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston (S.G.); and the HIV, Immunology, and Infectious Diseases Clinical Services Unit, St. Vincent's Hospital, Sydney (A.C.).

Address reprint requests to Dr. Grinspoon at the Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit St., LON207, Boston, MA 02114, or at sgrinspoon@partners.org.

Related Letters:

Cardiovascular Risk and Body-Fat Abnormalities in HIV-Infected Adults
Behrens G. M.N., Grinspoon S., Carr A.
Extract | Full Text | PDF  
N Engl J Med 2005; 352:1721-1722, Apr 21, 2005. Correspondence

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