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Volume 352:97-98 January 6, 2005 Number 1
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A Bitter Tale

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by Newman, L. S.
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To the Editor: In the Clinical Problem-Solving article by Newman et al. (Aug. 5 issue),1 concerning a case of accidental foxglove poisoning, the discussant fails to comment on the short QT interval evident on the initial electrocardiogram obtained in the emergency department. The QT interval appears to be 360 msec, and the corrected QT interval 280 msec. A short QT interval in the absence of hypercalcemia is specific for digoxin toxicity.2,3 Digitalis glycosides bind specifically to Na+/K+–ATPase, decreasing the active transport of sodium. The increase in intracellular sodium causes an augmentation of the exchange of intracellular sodium for . . . [Full Text of this Article]



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