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Previous Volume 352:1036-1038 March 10, 2005 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Primary brain tumors often resist treatment; the most common brain tumor in adults, glioblastoma, kills patients within a median of a year after diagnosis, even with aggressive surgical resection and radiotherapy. This dismal outcome has not substantially improved since the Brain Tumor Study Group published its results more than 25 years ago.¹ Numerous phase 3 trials have attempted to demonstrate a better outcome with the addition of chemotherapy (usually with a nitrosourea drug) to radiotherapy, but a significant prolongation of survival has never been observed, despite treatments with a variety of agents and delivery systems. There was a suggestion that . . . [Full Text of this Article]

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From the Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York.

Related Letters:

Treatment of Brain Tumors
Paulino A. C., Teh B. S., Sadeh M., Seiter K., Ashby L., LaRocca R., Ryken T., Aiken R. D., Rutkowski S., Ottensmeier H., Pietsch T., Stupp R., Hegi M. E., DeAngelis L. M.
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N Engl J Med 2005; 352:2350-2353, Jun 2, 2005. Correspondence

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