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Volume 352:1044-1046 March 10, 2005 Number 10
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Intradermal Vaccination against Influenza

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by La Montagne, J. R.
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by Belshe, R. B.
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by Kenney, R. T.
-PubMed Citation
To the Editor: I have been interested in the coverage by the media of the studies of intradermal influenza vaccination by Belshe et al.1 and Kenney et al.2 (Nov. 25 issue). We had quite similar findings — albeit without a control group — over 50 years ago.3


Thomas H. Weller, M.D.
56 Winding River Rd.
Needham, MA 02492

  1. Belshe RB, Newman FK, Cannon J, et al. Serum antibody responses after intradermal vaccination against influenza. N Engl J Med 2004;351:2286-2294. [Free Full Text]
  2. Kenney RT, Frech SA, Muenz LR, Villar CP, Glenn GM. Dose sparing with intradermal injection of influenza vaccine. N Engl J Med 2004;351:2295-2301. [Free Full Text]
  3. Weller TH, Cheever FS, Enders JF. Immunologic reactions following the intradermal inoculation of influenza A and B vaccine. Proc Soc Exp Biol Med 1948;67:96-101. 
 
To the Editor: In comparisons of intradermal and subcutaneous routes of inoculation, an important control is often omitted — namely, the comparison of equal doses of vaccine delivered by the two routes. This deficiency plagues the otherwise excellent studies of influenza vaccine . . . [Full Text of this Article]



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