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Previous Volume 352:1591-1594 April 14, 2005 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Therapy-related acute myeloid leukemia (AML), often presenting as therapy-related myelodysplasia, is the most serious long-term complication of cancer chemotherapy. This disease offers a unique opportunity to study leukemogenesis by relating specific cytogenetic and genetic abnormalities to the biologic effects of cytostatic agents. Two types of drugs, alkylating agents and topoisomerase II inhibitors, have been shown to induce therapy-related leukemia.

High risks of therapy-related myelodysplasia and AML were first reported in patients with multiple myeloma who had been treated with melphalan.¹ Subsequently, almost all other alkylating agents in clinical use have been shown to be leukemogenic in patients treated for a . . . [Full Text of this Article]

Source Information

From the Cytogenetics Laboratory, Rigshospitalet, Copenhagen.

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